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Gold-Catalyzed Carbene Transfer to Alkynes: Access to 2,4-Disubstituted Furans

Authors

  • Søren Kramer,

    1. Center for Insoluble Protein Structures, Department of Chemistry, Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C (Denmark)
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  • Prof. Dr. Troels Skrydstrup

    Corresponding author
    1. Center for Insoluble Protein Structures, Department of Chemistry, Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C (Denmark)
    • Center for Insoluble Protein Structures, Department of Chemistry, Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C (Denmark)
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  • We appreciate the generous financial support from the Danish National Research Foundation, H. Lundbeck A/S, the Carlsberg Foundation, the OChem Graduate School, and Aarhus University.

Abstract

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Ringschluss mit Gold: Die erste Gold-katalysierte intermolekulare Addition von Kohlenstoff-Yliden an terminale Alkine wird beschrieben (siehe Schema; DCE=Dichlorethan, Tf=Trifluormethansulfonyl). Anschließendes intramolekulares Abfangen des erzeugten Goldcarbens vervollständigt eine formale [3+2]-Cycloaddition in einer neuartigen Synthese von 2,4-disubstituierten Furanen.

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