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Turning “On” and “Off” a Pyridoxal 5′-Phosphate Mimic Using Light

Authors

  • Danielle Wilson,

    1. Department of Chemistry and 4D LABS, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A1S6 (Canada)
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  • Prof. Neil R. Branda

    Corresponding author
    1. Department of Chemistry and 4D LABS, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A1S6 (Canada)
    • Department of Chemistry and 4D LABS, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A1S6 (Canada)
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  • This research was supported by the Natural Sciences and Engineering Research Council (NSERC) of Canada, the Canada Research Chairs Program, and Simon Fraser University.

Abstract

original image

Licht wird verwendet, um ein photoresponsives Mimetikum des Cofactors Pyridoxalphosphat zwischen zwei Isomeren zu schalten, von denen nur eines die Racemisierung einer Aminosäure katalysieren kann. Die Funktion beruht auf dem Herstellen und Unterbrechen der elektronischen Kommunikation zwischen den beiden Katalysatorkomponenten, einem Aldehyd und einem Pyridiniumkation.

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