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Copper-Catalyzed Tandem C[BOND]N Bond Formation: An Efficient Annulative Synthesis of Functionalized Cinnolines†

  1. Catherine J. Ball1,
  2. Dr. Jeremy Gilmore2,
  3. Dr. Michael C. Willis1,*

Article first published online: 26 APR 2012

DOI: 10.1002/ange.201201529

Issue

Angewandte Chemie

Angewandte Chemie

Volume 124, Issue 23, pages 5816–5820, June 4, 2012

Additional Information

How to Cite

Ball, C. J., Gilmore, J. and Willis, M. C. (2012), Copper-Catalyzed Tandem C[BOND]N Bond Formation: An Efficient Annulative Synthesis of Functionalized Cinnolines. Angew. Chem., 124: 5816–5820. doi: 10.1002/ange.201201529

Author Information

  1. 1

    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA (UK) http://mcwillis.chem.ox.ac.uk/MCW/Home.html

  2. 2

    Lilly Research Centre, Eli Lilly and Company Ltd. Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH (UK)

*Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA (UK) http://mcwillis.chem.ox.ac.uk/MCW/Home.html

  1. †

    This work was supported by the EPSRC and Eli Lilly.

Publication History

  1. Issue published online: 30 MAY 2012
  2. Article first published online: 26 APR 2012
  3. Manuscript Revised: 21 MAR 2012
  4. Manuscript Received: 24 FEB 2012

Funded by

  • EPSRC
  • Eli Lilly

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Keywords:

  • Anellierungen;
  • Cinnoline;
  • Heterocyclen;
  • Kupferkatalyse;
  • Tandemprozesse
Thumbnail image of graphical abstract

Eine zu wenig beachtete Klasse aromatischer Heterocyclen, die Cinnoline, wird durch die Kombination aus einem leicht verfügbaren Kupferkatalysator, einem einfach aufgebauten Hydrazidnucleophil und bekannten difunktionalisierten Bausteinen in einem neuen und flexiblen Verfahren zugänglich (siehe Schema).

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