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Fluorochrome-Functionalized Magnetic Nanoparticles for High-Sensitivity Monitoring of the Polymerase Chain Reaction by Magnetic Resonance

Authors

  • Dr. David Alcantara,

    1. Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129 (USA)
    2. Instituto de Nanociencia de Aragon, Universidad de Zaragoza, 50018 Zaragoza (Spain)
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  • Dr. Yanyan Guo,

    1. Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129 (USA)
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  • Dr. Hushan Yuan,

    1. Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129 (USA)
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  • Dr. Craig J. Goergen,

    1. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129 (USA)
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  • Dr. Howard H. Chen,

    1. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129 (USA)
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  • Dr. Hoonsung Cho,

    1. Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129 (USA)
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  • Prof. Dr. David E. Sosnovik,

    1. Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129 (USA)
    2. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129 (USA)
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  • Prof. Dr. Lee Josephson

    Corresponding author
    1. Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129 (USA)
    2. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129 (USA)
    • Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129 (USA)
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  • This work was funded by NIH grants R01 EB009691 and R01 EB011996 to L.J. and R01 HL093038 (D.E.S.). D.A. was a recipient of a Marie Curie Fellowship (IOF, MRI Nanobiosensor).

Abstract

original image

Leicht zu sehen: Magnetische Nanopartikel mit Fluorochromen (rot), die in DNA (grün) interkalieren, bilden Mikroaggregate mit durch eine Polymerasekettenreaktion (PCR) erzeugter DNA. Diese Aggregate können schon nach wenigen PCR-Zyklen durch Kernspintomographie detektiert werden.

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