Nonblinking Plasmonic Quantum Dot Assemblies for Multiplex Biological Detection

Authors

  • Dr. Fayi Song,

    1. Institute of Biomaterials and Biomedical Engineering, Donnelly Centre for Cellular and Biomolecular Research, Chemical Engineering, Chemistry, Materials Science and Engineering, University of Toronto, Toronto, ON, M5S 3G9 (Canada)
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  • Peter S. Tang,

    1. Institute of Biomaterials and Biomedical Engineering, Donnelly Centre for Cellular and Biomolecular Research, Chemical Engineering, Chemistry, Materials Science and Engineering, University of Toronto, Toronto, ON, M5S 3G9 (Canada)
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  • Holly Durst,

    1. Department of Chemistry, University of Calgary, Calgary, AB, T2N 1N4 (Canada)
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  • Prof. Dr. David T. Cramb,

    1. Department of Chemistry, University of Calgary, Calgary, AB, T2N 1N4 (Canada)
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  • Prof. Dr. Warren C. W. Chan

    Corresponding author
    1. Institute of Biomaterials and Biomedical Engineering, Donnelly Centre for Cellular and Biomolecular Research, Chemical Engineering, Chemistry, Materials Science and Engineering, University of Toronto, Toronto, ON, M5S 3G9 (Canada)
    • Institute of Biomaterials and Biomedical Engineering, Donnelly Centre for Cellular and Biomolecular Research, Chemical Engineering, Chemistry, Materials Science and Engineering, University of Toronto, Toronto, ON, M5S 3G9 (Canada)
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  • W.C. and D.C. acknowledges the Canadian Institute of Health Research (MOP-93532; G118160781), Natural Sciences and Engineering Research Council of Canada (NETGP 35015-07, RGPIN 288231-09, and 203312-08), Canadian Research Chairs Program (950-203403), Canadian Foundation for Innovation, and Ontario Ministry of Research and Innovation for funding support. P. T. would like to acknowledge the Queen Elizabeth II Graduate Scholarships in Science and Technology (Canada) and the International Graduate Scholarships (Taiwan).

Abstract

original image

Schichtweise Polyelektrolyt-Abscheidung, bei der die stöchiometrische Zusammensetzung und der Abstand zwischen Quantenpunkten (QDs) und Goldnanopartikeln (GNPs) genau eingestellt wird, liefert die Titelsysteme. Die Konjugation biologischer Erkennungsmoleküle an diese Nano-Strichcodes ermöglicht eine gezielte Einschleusung in Zellen und eine verlängerte Verweilzeit bei minimaler Toxizität.

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