Get access

Acoustic Droplet Vaporization and Propulsion of Perfluorocarbon-Loaded Microbullets for Targeted Tissue Penetration and Deformation

Authors

  • Dr. Daniel Kagan,

    1. Department of Nanoengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA)
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Michael J. Benchimol,

    1. Department of Electrical and Computer Engineering, University of California San Diego (USA)
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Dr. Jonathan C. Claussen,

    1. Department of Nanoengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA)
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Dr. Erdembileg Chuluun-Erdene,

    1. Department of Nanoengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA)
    Search for more papers by this author
  • Dr. Sadik Esener,

    Corresponding author
    1. Department of Nanoengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA)
    • Department of Nanoengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA)
    Search for more papers by this author
  • Dr. Joseph Wang

    Corresponding author
    1. Department of Nanoengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA)
    • Department of Nanoengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA)
    Search for more papers by this author

  • We gratefully acknowledge financial support from the National Science Foundation (Award Number CBET 0853375), National Cancer Institute (NCI-5U54A119335-05), and the National Institutes of Health (NIH R25-CA153915). The authors thank Wei Gao for help in preparing the small MBs (length ca. 8 μm).

Abstract

original image

Ultraschallinduzierte Verdampfung eines Perfluorkohlenwasserstoffs (PFC) in Mikrogeschossen verleiht diesen die Kraft, um Zellgewebe zu durchdringen, zu spalten und zu verformen, was nützlich sein kann für den Wirkstofftransport oder präzise Nanooperationen. Die Geschosse haben innen eine Goldschicht, die die Konjugation einer Monoschicht aus thioliertem Cysteamin (grün im Bild) ermöglicht, worauf über elektrostatische Wechselwirkungen PFC-Tröpfchen (violette Tropfen) angebracht werden.

Get access to the full text of this article

Ancillary