Using an Electrical Potential to Reversibly Switch Surfaces between Two States for Dynamically Controlling Cell Adhesion

Authors

  • Dr. Cheuk Chi Albert Ng,

    1. School of Chemistry and Australian Centre for NanoMedicine, The University of New South Wales, Sydney NSW 2052 (Australia)
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  • Dr. Astrid Magenau,

    1. Centre for Vascular Research and Australian Centre for NanoMedicine, The University of New South Wales, Sydney NSW 2052 (Australia)
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  • Siti Hawa Ngalim,

    1. Centre for Vascular Research and Australian Centre for NanoMedicine, The University of New South Wales, Sydney NSW 2052 (Australia)
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  • Dr. Simone Ciampi,

    1. School of Chemistry and Australian Centre for NanoMedicine, The University of New South Wales, Sydney NSW 2052 (Australia)
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  • Dr. Muthukumar Chockalingham,

    1. School of Chemistry and Australian Centre for NanoMedicine, The University of New South Wales, Sydney NSW 2052 (Australia)
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  • Dr. Jason Brian Harper,

    1. School of Chemistry and Australian Centre for NanoMedicine, The University of New South Wales, Sydney NSW 2052 (Australia)
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  • Prof. Dr. Katharina Gaus,

    1. Centre for Vascular Research and Australian Centre for NanoMedicine, The University of New South Wales, Sydney NSW 2052 (Australia)
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  • Prof. Dr. John Justin Gooding

    Corresponding author
    1. School of Chemistry and Australian Centre for NanoMedicine, The University of New South Wales, Sydney NSW 2052 (Australia)
    • School of Chemistry and Australian Centre for NanoMedicine, The University of New South Wales, Sydney NSW 2052 (Australia)
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  • This research was supported by the Discovery Projects Funding Scheme of the Australian Research Council under grant number DP1094564.

Abstract

original image

Intelligente Oberflächen wurden hergestellt und charakterisiert, die zwei Arten von Molekülen tragen: anwuchsverhindernde Moleküle mit endständigen geladenen funktionellen Gruppen sowie Moleküle, die mit RGD-Peptiden für die Zelladhäsion terminiert sind (siehe Bild). Durch Anlegen von Spannungen von +300 oder −300 mV konnten die Oberflächen zwischen zelladhäsiv und zellabweisend dynamisch geschaltet werden.

Ancillary