These authors contributed equally to this work.
Zuschrift
High-Throughput Interrogation of Ligand Binding Mode Using a Fluorescence-Based Assay†
Article first published online: 22 JUN 2012
DOI: 10.1002/ange.201202660
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Śledź, P., Lang, S., Stubbs, C. J. and Abell, C. (2012), High-Throughput Interrogation of Ligand Binding Mode Using a Fluorescence-Based Assay . Angew. Chem., 124: 7800–7803. doi: 10.1002/ange.201202660
- †
We thank Dr. Marko Hyvönen for helpful discussions and Dr. Dima Chirgadze for maintaining the Crystallographic X-ray Facility at the Department of Biochemistry, University of Cambridge. This work was supported by the Wellcome Trust. Furthermore, we acknowledge the funding from the Gates Cambridge Trust and St. Edmund’s College (P.Ś.), German Academic Exchange Service—DAAD (S.L.), and Cancer Research UK (C.J.S.). The use of beamtime at the European Synchrotron Radiation Facility is gratefully acknowledged.
- ‡
These authors contributed equally to this work.
Publication History
- Issue published online: 25 JUL 2012
- Article first published online: 22 JUN 2012
- Manuscript Received: 5 APR 2012
Funded by
- Funded Access
- Wellcome Trust
- Gates Cambridge Trust
- St. Edmund’s College
- German Academic Exchange Service—DAAD
- Cancer Research UK
- 1, , , , , , Nat. Biotechnol. 2000, 18, 1105–1108.
- 2, , , , , , Angew. Chem. 2005, 117, 4244–4247;Angew. Chem. Int. Ed. 2005, 44, 4172–4175.Direct Link:
- 3, , , , , , J. Am. Chem. Soc. 2010, 132, 4544–4545.
- 4
- 5
- 6
- 7, , , , , , , , , , et al., Nat. Struct. Mol. Biol. 2009, 16, 876–U104.
- 8
- 9, , , , , , , , Angew. Chem. 2011, 123, 4089–4092;Angew. Chem. Int. Ed. 2011, 50, 4003–4006.Direct Link:
- 10, , , , , , , , , Nat. Chem. Biol. 2011, 7, 595–601.
- 11, , , , , , , Anal. Biochem. 2004, 332, 153–159.
- 12, , , , , , , , , , et al., Bioorg. Med. Chem. Lett. 2005, 15, 765–770.
- 13, , , , , , Angew. Chem. 2009, 121, 8604–8608;Angew. Chem. Int. Ed. 2009, 48, 8452–8456.Direct Link:
- 14, , , , , , , , , , Biophys. J. 2008, 95, 3222–3231.
- 15, , , , , , , , , ACS Chem. Biol. 2012, 7, 805–810.

1521-3757/asset/olbannerleft.gif?v=1&s=955f4ad069e7907a938ccdcd8ec67e6859f54887)
1521-3757/asset/olbannerright.gif?v=1&s=369b1aa14838487fa1f01dd4dcee8eca018510b4)
