Exploration of Forbidden Povarov Processes as a Source of Unexpected Reactivity: A Multicomponent Mannich–Ritter Transformation

Authors

  • Sara Preciado,

    1. Barcelona Science Park, Baldiri Reixac 10–12, 08028 Barcelona (Spain)
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  • Esther Vicente-García,

    1. Barcelona Science Park, Baldiri Reixac 10–12, 08028 Barcelona (Spain)
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  • Salomé Llabrés,

    1. Department of Physical Chemistry and Institute of Biomedicine (IBUB), Faculty of Pharmacy, University of Barcelona, Avda Diagonal 643, 08028 Barcelona (Spain)
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  • Prof. F. Javier Luque,

    1. Department of Physical Chemistry and Institute of Biomedicine (IBUB), Faculty of Pharmacy, University of Barcelona, Avda Diagonal 643, 08028 Barcelona (Spain)
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  • Prof. Rodolfo Lavilla

    Corresponding author
    1. Barcelona Science Park, Baldiri Reixac 10–12, 08028 Barcelona (Spain)
    2. Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Avda Joan XXIII s/n, 08028 Barcelona (Spain)
    • Barcelona Science Park, Baldiri Reixac 10–12, 08028 Barcelona (Spain)
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  • This work was supported by DGICYT—Spain (projects BQUCTQ2009-07758 and SAF2011-27642), Generalitat de Catalunya (projects 2009SGR 1024 and 298), CESCA, and Grupo Ferrer (Barcelona, Spain).

Abstract

original image

Geheimes Fenster: Povarov-Prozesse mit geometrisch oder elektronisch eingeschränkten Iminen ergeben nicht die Anti-Bredt-Tetrahydrochinoline, sondern führen über neuartige Reaktionswege zu hoch funktionalisierten Strukturen (siehe Schema; LA=Lewis-Säure). Die Untersuchung dieser „verbotenen“ Wege kann sich bei der Entdeckung neuer Mehrkomponentenreaktionen als nützlich erweisen.

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