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Aptamer-Based Origami Paper Analytical Device for Electrochemical Detection of Adenosine†

  1. Hong Liu1,
  2. Dr. Yu Xiang2,
  3. Prof. Yi Lu2,
  4. Prof. Richard M. Crooks1,*

Article first published online: 25 MAY 2012

DOI: 10.1002/ange.201202929

Issue

Angewandte Chemie

Angewandte Chemie

Volume 124, Issue 28, pages 7031–7034, July 9, 2012

Additional Information

How to Cite

Liu, H., Xiang, Y., Lu, Y. and Crooks, R. M. (2012), Aptamer-Based Origami Paper Analytical Device for Electrochemical Detection of Adenosine. Angew. Chem., 124: 7031–7034. doi: 10.1002/ange.201202929

Author Information

  1. 1

    Department of Chemistry and Biochemistry, Center for Electrochemistry, The University of Texas at Austin, Austin, TX 78712-0165 (USA)

  2. 2

    Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA)

*Department of Chemistry and Biochemistry, Center for Electrochemistry, The University of Texas at Austin, Austin, TX 78712-0165 (USA)

  1. †

    We thank Dr. Bingling Li for DNA characterization. R.M.C. acknowledges sponsorship of this project by the Defense Advanced Research Projects Agency (Contract No. HR0011-12-2-0003) and the Defense Threat Reduction Agency (Contract No. HDTRA1-11-1-0005). The content of the information does not necessarily reflect the position or the policy of the US Government. No official endorsement should be inferred. Y.L. acknowledges support from the National Institutes of Health (ES16865). We also thank Dr. Antonio J. Ricco for providing several important technical suggestions.

Publication History

  1. Issue published online: 4 JUL 2012
  2. Article first published online: 25 MAY 2012
  3. Manuscript Received: 17 APR 2012

Funded by

  • Defense Advanced Research Projects Agency. Grant Number: HR0011-12-2-0003
  • Defense Threat Reduction Agency. Grant Number: HDTRA1-11-1-0005
  • National Institutes of Health. Grant Number: ES16865

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Keywords:

  • Aptamere;
  • Biosensoren;
  • Elektrochemie;
  • Fluidikchips aus Papier;
  • Stromverstärkung
Thumbnail image of graphical abstract

Paper-Biosensoren: Ein Origami-Sensor kann auf ein Blatt Papier gedruckt, zu einer dreidimensionalen Fluidikeinheit gefaltet und durch thermisches Laminieren versiegelt werden. Das im Kanal eingeschlossene Aptamer bindet einen Analyt und setzt ein Enzym frei, wodurch ein Signal erzeugt wird, das mit einem Digitalmultimeter detektiert werden kann.

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