Advertisement

Aptamer-Based Origami Paper Analytical Device for Electrochemical Detection of Adenosine

Authors

  • Hong Liu,

    1. Department of Chemistry and Biochemistry, Center for Electrochemistry, The University of Texas at Austin, Austin, TX 78712-0165 (USA)
    Search for more papers by this author
  • Dr. Yu Xiang,

    1. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA)
    Search for more papers by this author
  • Prof. Yi Lu,

    1. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA)
    Search for more papers by this author
  • Prof. Richard M. Crooks

    Corresponding author
    1. Department of Chemistry and Biochemistry, Center for Electrochemistry, The University of Texas at Austin, Austin, TX 78712-0165 (USA)
    • Department of Chemistry and Biochemistry, Center for Electrochemistry, The University of Texas at Austin, Austin, TX 78712-0165 (USA)
    Search for more papers by this author

  • We thank Dr. Bingling Li for DNA characterization. R.M.C. acknowledges sponsorship of this project by the Defense Advanced Research Projects Agency (Contract No. HR0011-12-2-0003) and the Defense Threat Reduction Agency (Contract No. HDTRA1-11-1-0005). The content of the information does not necessarily reflect the position or the policy of the US Government. No official endorsement should be inferred. Y.L. acknowledges support from the National Institutes of Health (ES16865). We also thank Dr. Antonio J. Ricco for providing several important technical suggestions.

Abstract

original image

Paper-Biosensoren: Ein Origami-Sensor kann auf ein Blatt Papier gedruckt, zu einer dreidimensionalen Fluidikeinheit gefaltet und durch thermisches Laminieren versiegelt werden. Das im Kanal eingeschlossene Aptamer bindet einen Analyt und setzt ein Enzym frei, wodurch ein Signal erzeugt wird, das mit einem Digitalmultimeter detektiert werden kann.

Ancillary