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Imageable Antigen-Presenting Gold Nanoparticle Vaccines for Effective Cancer Immunotherapy In Vivo

Authors

  • In-Hyun Lee,

    1. Biological Science Department, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro,Yuseong-gu, Daejeon 305-701 (South Korea)
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  • Ho-Keun Kwon,

    1. School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Gwangju 500-712 (South Korea)
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  • Sukyung An,

    1. Biological Science Department, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro,Yuseong-gu, Daejeon 305-701 (South Korea)
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  • Daejin Kim,

    1. Biological Science Department, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro,Yuseong-gu, Daejeon 305-701 (South Korea)
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  • Sunghyun Kim,

    1. Biological Science Department, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro,Yuseong-gu, Daejeon 305-701 (South Korea)
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  • Mi Kyung Yu,

    1. Biological Science Department, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro,Yuseong-gu, Daejeon 305-701 (South Korea)
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  • Prof. Jae-Hyuk Lee,

    1. Department of Pathology, Jeonnam National University Medical School, 5 Hak1-dong, Gwangju 501-746, (South Korea)
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  • Dr. Tae-Sup Lee,

    1. Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), 215-4 Gongneung-Dong, Nowon-Gu, Seoul 139-706 (South Korea)
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  • Prof. Sin-Hyeog Im,

    1. School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Gwangju 500-712 (South Korea)
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  • Prof. Sangyong Jon

    Corresponding author
    1. Biological Science Department, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro,Yuseong-gu, Daejeon 305-701 (South Korea)
    • Biological Science Department, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro,Yuseong-gu, Daejeon 305-701 (South Korea)
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  • This study was supported by the Converging Research Center Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (grant number: 2011K000797 and 20120006074) and by a grant from Cell Dynamics Research Center, NRF (grant number: 20120000771).

Abstract

original image

Goldnanopartikel (AuNPs) wurden mit einem rot fluoreszierenden Protein (RFP, rosafarbene Formen im Bild) als Modellantigen und einem Oligonukleotid (CpG), das die Immunantwort stimuliert, funktionalisiert. Diese AuNPs ermöglichten bei Verwendung als Krebsimpfstoffe in einem Tumormodell den effizienten Transport eines Antigens zum Zielort, die Verfolgung des Impfstoffs mithilfe nichtinvasiver klinischer Bildgebung sowie Vorbeugung und Behandlung von Krebs.

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