Photocontrolled Targeted Drug Delivery: Photocaged Biologically Active Folic Acid as a Light-Responsive Tumor-Targeting Molecule

Authors

  • Nien-Chu Fan,

    1. Department of Chemistry, National Tsing Hua University, Hsinchu 30013 (Taiwan)
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    • These authors contributed equally to this work.

  • Prof. Fong-Yu Cheng,

    1. Institute of Oral Medicine, National Cheng Kung University, Tainan 701 (Taiwan)
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    • These authors contributed equally to this work.

  • Prof. Ja-an Annie Ho,

    Corresponding author
    1. Department of Biochemical Science and Technology, National Taiwan University, Taipei 10167 (Taiwan)
    2. Department of Chemistry, National Tsing Hua University, Hsinchu 30013 (Taiwan)
    • Department of Biochemical Science and Technology, National Taiwan University, Taipei 10167 (Taiwan)
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  • Prof. Chen-Sheng Yeh

    Corresponding author
    1. Department of Chemistry, Center for Micro/Nano Science and Technology, and Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 701, Taiwan
    • Department of Chemistry, Center for Micro/Nano Science and Technology, and Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 701, Taiwan
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  • This work was supported by the National Science Council of Taiwan. (NSC 100-2627-M-006-007, NSC 100-2119-M-006-021, and 98-2113-M-002-025-MY3).

Abstract

original image

Lichtkontrolliert: Ein Wirkstoff gegen Krebs (rote Punkte im Bild) wurde in bioabbaubaren Nanopartikeln eingeschlossen, die photoaktivierbare Folsäuregruppen auf der Oberfläche tragen. Nach Bestrahlung wird die Photoschutzgruppe (grün) abgespalten, und die freie Folsäuregruppe, ein tumorbindendes Agens, bindet an Folsäurerezeptoren auf Zelloberflächen und führt so zu spezifischer Aufnahme durch die Zielzellen.

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