Zuschrift

Ceria Nanoparticles that can Protect against Ischemic Stroke†

  1. Dr. Chi Kyung Kim1,‡,
  2. Taeho Kim2,‡,
  3. In-Young Choi1,
  4. Min Soh2,
  5. Dr. Dohoung Kim1,
  6. Young-Ju Kim1,
  7. Dr. Hyunduk Jang1,
  8. Hye-Sung Yang1,
  9. Dr. Jun Yup Kim1,
  10. Dr. Hong-Kyun Park1,
  11. Dr. Seung Pyo Park2,
  12. Sangseung Park2,
  13. Dr. Taekyung Yu2,
  14. Prof. Byung-Woo Yoon1,
  15. Prof. Seung-Hoon Lee1,*,
  16. Prof. Taeghwan Hyeon2,*

Article first published online: 11 SEP 2012

DOI: 10.1002/ange.201203780

Issue

Angewandte Chemie

Angewandte Chemie

Volume 124, Issue 44, pages 11201–11205, October 29, 2012

Additional Information

How to Cite

Kim, C. K., Kim, T., Choi, I.-Y., Soh, M., Kim, D., Kim, Y.-J., Jang, H., Yang, H.-S., Kim, J. Y., Park, H.-K., Park, S. P., Park, S., Yu, T., Yoon, B.-W., Lee, S.-H. and Hyeon, T. (2012), Ceria Nanoparticles that can Protect against Ischemic Stroke . Angew. Chem., 124: 11201–11205. doi: 10.1002/ange.201203780

Author Information

  1. 1

    Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)

  2. 2

    Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)

  1. ‡

    These authors contributed equally to this work.

*Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)

  1. †

    This work was supported by a grant of the Korean Health Technology R&D Project, Korean Ministry of Health & Welfare (A111014).

  2. ‡

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 24 OCT 2012
  2. Article first published online: 11 SEP 2012
  3. Manuscript Revised: 30 JUL 2012
  4. Manuscript Received: 16 MAY 2012

Funded by

  • Korean Health Technology R&D Project
  • Korean Ministry of Health & Welfare. Grant Number: A111014

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Keywords:

  • Apoptose;
  • Cerdioxidnanopartikel;
  • Ischämischer Hirninfarkt;
  • Reaktive Sauerstoffspezies;
  • Therapeutika
Thumbnail image of graphical abstract

Einheitliche 3 nm große Cerdioxidnanopartikel können vor ischämischen Hirninfarkten schützen, indem sie reaktive Sauerstoffspezies (ROS) abfangen und die Apoptose zurückdrängen. PEGylierte Cerdioxidnanopartikel waren in vitro gegen ROS-induzierten Zelltod wirksam. Optimale Dosen solcher Nanopartikel verringerten das Infarktvolumen und verlangsamten den ischämischen Zelltod.

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