These authors contributed equally to this work.
Self-Resistance to an Antitumor Antibiotic: A DNA Glycosylase Triggers the Base-Excision Repair System in Yatakemycin Biosynthesis†
Article first published online: 17 SEP 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 124, Issue 42, pages 10684–10688, October 15, 2012
How to Cite
Xu, H., Huang, W., He, Q.-L., Zhao, Z.-X., Zhang, F., Wang, R., Kang, J. and Tang, G.-L. (2012), Self-Resistance to an Antitumor Antibiotic: A DNA Glycosylase Triggers the Base-Excision Repair System in Yatakemycin Biosynthesis . Angew. Chem., 124: 10684–10688. doi: 10.1002/ange.201204109
We thank Prof. Yasuhiro Igarashi (Toyama Prefectural University,Japan) for providing the strain Streptomyces sp. TP-A0356 and yatakemycin; Prof. Magnar Bjoras (University of Oslo, Norway), for providing plasmids pT7SCII-AlkC and pT7SCII-AlkD that encode the alkC and alkD genes; and the lab of Prof. Zixin Deng of Shanghai JiaoTong University for support in obtaining MS data. This work was financially supported by grants from the National Basic Research Program of China (973 Program) 2009CB118901 and 2010CB833200, and the National Natural Science Foundation of China (90913005, 20832009, and 20921091).
- Issue published online: 10 OCT 2012
- Article first published online: 17 SEP 2012
- Manuscript Received: 27 MAY 2012
- National Basic Research Program of China. Grant Numbers: 2009CB118901, 2010CB833200
- National Natural Science Foundation of China. Grant Numbers: 90913005, 20832009, 20921091
Options for accessing this content:
- If you have access to this content through a society membership, please first log in to your society website.
- If you would like institutional access to this content, please recommend the title to your librarian.
- Login via other institutional login options http://onlinelibrary.wiley.com/login-options.
- You can purchase online access to this Article for a 24-hour period (price varies by title)
- New Users: Please register, then proceed to purchase the article.
Registered Users please login:
- Access your saved publications, articles and searches
- Manage your email alerts, orders and subscriptions
- Change your contact information, including your password
Please register to:
- Save publications, articles and searches
- Get email alerts
- Get all the benefits mentioned below!