These authors contributed equally to the work.
Site-Specific Identification of an Aβ Fibril–Heparin Interaction Site by Using Solid-State NMR Spectroscopy†
Article first published online: 14 NOV 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 124, Issue 52, pages 13317–13320, December 21, 2012
How to Cite
Madine, J., Pandya, M. J., Hicks, M. R., Rodger, A., Yates, E. A., Radford, S. E. and Middleton, D. A. (2012), Site-Specific Identification of an Aβ Fibril–Heparin Interaction Site by Using Solid-State NMR Spectroscopy . Angew. Chem., 124: 13317–13320. doi: 10.1002/ange.201204459
The work was funded by the Wellcome Trust (grant number 088563/B/09/Z). The UK 850 MHz solid-state NMR Facility was funded by EPSRC, BBSRC, and the University of Warwick, including funding through Birmingham Science City Advanced Materials Projects 1 and 2 supported by Advantage West Midlands and the European Regional Development Fund. We thank James Ault, University of Leeds, for mass spectrometry, Mark Tully, University of Liverpool, for heparinase enzyme, and Dinu Iuga, University of Warwick, for his assistance with the 850 MHz SSNMR. The clone for Aβ was kindly provided by Sara Linse, Lund University, and Dominic Walsh, Harvard Institute of Medicine. Aβ fibril seeds and pdb coordinate files were generously provided by Robert Tycko, NIH, Bethesda (USA).
- Issue published online: 18 DEC 2012
- Article first published online: 14 NOV 2012
- Manuscript Revised: 4 OCT 2012
- Manuscript Received: 8 JUN 2012
- Funded Access
- Wellcome Trust. Grant Number: 088563/B/09/Z