Creation of Pure Nanodrugs and Their Anticancer Properties

Authors

  • Dr. Hitoshi Kasai,

    Corresponding author
    1. Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)
    • Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)
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  • Dr. Tatsuya Murakami,

    1. World Premier International Research Center Initiative, Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8302 (Japan)
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  • Yoshikazu Ikuta,

    1. Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)
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  • Yoshitaka Koseki,

    1. Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)
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  • Dr. Koichi Baba,

    1. Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871 (Japan)
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  • Prof. Hidetoshi Oikawa,

    1. Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)
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  • Prof. Hachiro Nakanishi,

    1. Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)
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  • Dr. Masahiro Okada,

    1. Graduate School of Bioscience and Biotechnology, Chubu University, Kasugai-shi, Aichi 487-8501 (Japan)
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  • Mitsuru Shoji,

    1. Faculty of Pharmacy, Keio University, Minato-ku, Tokyo 105-8512 (Japan)
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  • Prof. Minoru Ueda,

    1. Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578 (Japan)
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  • Prof. Hiroshi Imahori,

    1. World Premier International Research Center Initiative, Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8302 (Japan)
    2. Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510 (Japan)
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  • Prof. Mitsuru Hashida

    1. World Premier International Research Center Initiative, Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8302 (Japan)
    2. Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501 (Japan)
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  • The Asahi Glass Foundation and the JST programs of PREST “Search for Nanomanufacturing Technology and Its Development” (Supervisor: Dr. Naoki Yokoyama) and Adaptable and Seamless Technology Transfer Program through Target-driven R&D have been greatly supportive in this study. We would also like to thank Dr. Jun Matsui and Dr. Takahiro Muraoka of IMRAM, Tohoku University, who provided fruitful discussion. In addition, we received generous support from Nao Naohara, Sayaka Ishibane, Akie Takanashi, Shoko Yamamoto, and Kenji Sugai in relation to the experimentation performed herein. We are very grateful to Prof. Shigefumi Kuwahara of Faculty of Agriculture, Tohoku University, for help with the organic synthesis and spectroscopic measurements.

Abstract

original image

Ein wasserunlöslicher Wirkstoff kann in Form von Nanopartikeln vom menschlichen Körper aufgenommen werden. Mithilfe einer Umfällungsmethode wurden 50 nm große Nanopartikel aus dimerisiertem SN-38, einem antitumoraktiven Camptothecin-Derivat, erhalten. Die Partikel bilden stabile wässrige Dispersionen und können in Krebszellen eindringen, um deren Fortpflanzung stärker zu hemmen als Irinotecan.

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