Enantioselective Aza-Morita–Baylis–Hillman Reactions of Acrylonitrile Catalyzed by Palladium(II) Pincer Complexes having C2-Symmetric Chiral Bis(imidazoline) Ligands

Authors

  • Kengo Hyodo,

    1. Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555 (Japan)
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  • Prof. Shuichi Nakamura,

    Corresponding author
    1. Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555 (Japan)
    • Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555 (Japan)
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  • Prof. Norio Shibata

    Corresponding author
    1. Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555 (Japan)
    • Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555 (Japan)
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  • This work was supported by Teijin Pharma Award in Synthetic Organic Chemistry (Japan) and a Sasagawa Scientific Research Grant from the Japan Science Society.

Abstract

original image

Schlicht effizient: Eine Aza-Morita-Baylis-Hillman-Reaktion zwischen Acrylnitril und verschiedenen Iminen in Gegenwart chiraler Phebim-PdII-Komplexe (1) ergibt die Produkte in hervorragenden Ausbeuten und Enantioselektivitäten (siehe Schema). Somit steht ein leichtes und effizientes Syntheseverfahren für funktionalisierte α-Methylen-β-aminonitrile und deren Derivate zur Verfügung.

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