Innenrücktitelbild: Catalytic Asymmetric [4+2] Annulation Initiated by an Aza-Rauhut–Currier Reaction: Facile Entry to Highly Functionalized Tetrahydropyridines (Angew. Chem. 31/2012)

Authors

  • Zugui Shi,

    1. College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, 16 Xue-Lin Street, Hangzhou 310036, Zhejiang (China)
    2. Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)
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  • Peiyuan Yu,

    1. College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, 16 Xue-Lin Street, Hangzhou 310036, Zhejiang (China)
    2. Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)
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  • Prof. Dr. Teck-Peng Loh,

    Corresponding author
    1. Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)
    2. Department of Chemistry, University of Sciences and Technology of China, Hefei 230026, Anhui (China)
    • Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)
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  • Prof. Dr. Guofu Zhong

    Corresponding author
    1. College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, 16 Xue-Lin Street, Hangzhou 310036, Zhejiang (China)
    2. Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)
    • College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, 16 Xue-Lin Street, Hangzhou 310036, Zhejiang (China)
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Abstract

original image

Die Kombination bekannter Umwandlungen kann extrem leistungsfähige neue Reaktionskaskaden hervorbringen. In der Zuschrift auf S. 7945 ff. verknüpfen G. Zhong, T. P. Loh et al. eine intermolekulare Aza-Rauhut-Currier-Reaktion mit einer intramolekularen Cyclisierung zur Synthese hoch funktionalisierter Tetrahydropyridine (THPs). Der organokatalytische [4+2]-Ringschluss von Vinylketonen mit N-Sulfonyl-1-aza-1,3-dienen liefert die THPs mit guter bis hervorragender Stereoselektivität. Das Bild zeigt einen Vorschlag für den Reaktionsmechanismus.

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