Efficient Assembly of Iminodicarboxamides by a “Truly” Four-Component Reaction

Authors

  • Kareem Khoury,

    1. Departments of Pharmaceutical Sciences and Chemistry, University of Pittsburgh, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261 (USA)
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  • Dr. Mantosh K. Sinha,

    1. Departments of Pharmaceutical Sciences and Chemistry, University of Pittsburgh, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261 (USA)
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  • Dr. Tadamichi Nagashima,

    1. Departments of Pharmaceutical Sciences and Chemistry, University of Pittsburgh, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261 (USA)
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  • Eberhardt Herdtweck,

    1. Technische Universität München, Department Chemie, Lehrstuhl für Anorganische Chemie, Lichtenbergstrasse 4, 85747 Garching bei Munchen (Germany)
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  • Prof. Alexander Dömling

    Corresponding author
    1. Departments of Pharmaceutical Sciences and Chemistry, University of Pittsburgh, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261 (USA)
    2. University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen (The Netherlands) http://adoemling.wix.com/laboratories
    • Departments of Pharmaceutical Sciences and Chemistry, University of Pittsburgh, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261 (USA)
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Errata

This article is corrected by:

  1. Errata: Berichtigung: Efficient Assembly of Iminodicarboxamides by a “Truly” Four-Component Reaction Volume 125, Issue 21, 5535, Article first published online: 10 May 2013

  • This work was supported by the NIH grants 1R21GM087617-01, 1P41GM094055-01, and 1R01GM097082-01.

Abstract

original image

Unbegrenzte Möglichkeiten: Ähnlich wie eine Galaxie aus Millionen von Sternen besteht, kann ein System von Mehrkomponentenreaktionen (MCRs) in Millionen von Verbindungen resultieren. Die MCR von α-Aminosäuren, Oxoverbindungen, Isocyaniden und Aminen führt zu zahllosen und diversen Verbindungen und hat folglich ein enormes Potenzial für die Wirkstoffentwicklung und das Katalysator-Screening.

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