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Changing the Enzyme Reaction Rate in Magnetic Nanosuspensions by a Non-Heating Magnetic Field

Authors

  • Prof. Dr. Natalia L. Klyachko,

    1. Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, 96025 Nebraska Medical Center, Omaha, NE 68198 (USA)
    2. Laboratory for Chemical Design of Bionanomaterials, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, 119991 (Russia)
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    • These authors contributed equally to this work.

  • Dr. Marina Sokolsky-Papkov,

    1. Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, 96025 Nebraska Medical Center, Omaha, NE 68198 (USA)
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    • These authors contributed equally to this work.

  • Nikorn Pothayee,

    1. Macromolecules and Interfaces Institute, Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 (USA)
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  • Maria V. Efremova,

    1. Laboratory for Chemical Design of Bionanomaterials, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, 119991 (Russia)
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  • Dr. Dmitry A. Gulin,

    1. Laboratory for Chemical Design of Bionanomaterials, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, 119991 (Russia)
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  • Nipon Pothayee,

  • Artem A. Kuznetsov,

    1. Laboratory for Chemical Design of Bionanomaterials, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, 119991 (Russia)
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  • Dr. Alexander G. Majouga,

    1. Laboratory for Chemical Design of Bionanomaterials, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, 119991 (Russia)
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  • Prof. Judy S. Riffle,

    1. Macromolecules and Interfaces Institute, Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 (USA)
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  • Prof. Dr. Yuri I. Golovin,

    1. Laboratory for Chemical Design of Bionanomaterials, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, 119991 (Russia)
    2. Nanocenter of Tambov State University, Tambov State University, Tambov, 392000 (Russia)
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  • Prof. Dr. Alexander V. Kabanov

    Corresponding author
    1. Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, 96025 Nebraska Medical Center, Omaha, NE 68198 (USA)
    2. Laboratory for Chemical Design of Bionanomaterials, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, 119991 (Russia)
    • Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, 96025 Nebraska Medical Center, Omaha, NE 68198 (USA)
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  • The authors thank U.S. National Institutes of Health, RR021937, Russian Ministry of Science and Education, 11.G34.31.0004 (both to A.V.K.), and the U.S. National Science Foundation Materials World Network program, DMR-0805179 and the U.S. National Science Foundation contract DMR 0909065 (to J.S.R.). The authors are grateful to T. Bargar (UNMC) for carrying out TEM experiments, Dr. I. Khutsishvili (UNMC) for CD measurements, and Nazar Filonov (COBRE Nanomaterials Core Characterization) for ICP-MS measurements.

Abstract

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Desaktiviert und deformiert werden Enzyme, die auf magnetischen Nanopartikeln (MNPs) immobilisiert sind, beim Anlegen von magnetischen Feldern. Diese Veränderungen resultieren aus der erneuten Ausrichtung der MNPs im AC-Magnetfeld, die mit den MNPs verknüpfte Polymerketten unter Belastung setzt. Für immobilisierte Enzymmoleküle auf einem MNP-Aggregat ergeben sich dadurch Deformationen und irreversible (oder lange anhaltende) Konformationsänderungen.

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