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Organocatalytic Amidation and Esterification of Aldehydes with Activating Reagents by a Cross-Coupling Strategy

Authors

  • Dr. Bin Tan,

    1. The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
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  • Dr. Narihiro Toda,

    1. The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
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  • Prof. Dr. Carlos F. Barbas III

    Corresponding author
    1. The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    • The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
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  • Research support from the Skaggs Institute for Chemical Biology is gratefully acknowledged. N.T. also thanks Daiichi Sankyo Co., Ltd. for financial support.

Abstract

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Bildung bei Bedarf: Die Titelreaktion nutzt N-Hydroxyimide, Hexafluor-2-propanol und Sulfonimide. Die gebildeten Zwischenstufen können direkt in Amide oder Ester überführt werden. Diese einfache Methode verwendet leicht erhältliche Ausgangsverbindungen, und die neu entdeckten aktivierenden Reagentien sollten breite Anwendung in der Synthese von Amiden und Estern finden.

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