Zuschrift

High Antitumor Activity of Highly Resistant Salan–Titanium(IV) Complexes in Nanoparticles: An Identified Active Species†

  1. Sigalit Meker1,
  2. Katrin Margulis-Goshen2,
  3. Ester Weiss1,
  4. Prof. Shlomo Magdassi2,*,
  5. Prof. Edit Y. Tshuva1,*

Article first published online: 7 SEP 2012

DOI: 10.1002/ange.201205973

Issue

Angewandte Chemie

Angewandte Chemie

Volume 124, Issue 42, pages 10667–10669, October 15, 2012

Additional Information

How to Cite

Meker, S., Margulis-Goshen, K., Weiss, E., Magdassi, S. and Tshuva, E. Y. (2012), High Antitumor Activity of Highly Resistant Salan–Titanium(IV) Complexes in Nanoparticles: An Identified Active Species . Angew. Chem., 124: 10667–10669. doi: 10.1002/ange.201205973

Author Information

  1. 1

    Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904 (Israel) http://chem.ch.huji.ac.il/∼tshuva

  2. 2

    Casali Institute of Applied Chemistry, Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904 (Israel)

*Casali Institute of Applied Chemistry, Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904 (Israel)

  1. †

    We thank Dr. Shmuel Cohen for crystallography work. Funding was received from the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement (No.239603), and partially from the Israel Science Foundation (grant No.124/09) and Lower Saxony Ministry of Science.

Publication History

  1. Issue published online: 10 OCT 2012
  2. Article first published online: 7 SEP 2012
  3. Manuscript Received: 26 JUL 2012

Funded by

  • European Research Council. Grant Number: 239603
  • Israel Science Foundation. Grant Number: 124/09
  • Lower Saxony Ministry of Science

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (566K)

Keywords:

  • Cisplatin;
  • Ligandendesign;
  • Nanoformulierung;
  • Titan;
  • Tumortherapeutika
Thumbnail image of graphical abstract

Das nanoformulierte dreikernige Hydrolyseprodukt eines Bis(alkoxo)-Salan-TiIV-Komplexes zeigt hohe Antitumoraktivität (siehe Bild). Weitere hochstabile einkernige Derivate zeigen ebenfalls hohe Aktivität nach ihrer Formulierung in Nanopartikeln und bestätigen damit, dass TiIV hohe Zytotoxizität mit kontrollierter biologischer Funktion bereitstellen kann.

View Full Article with Supporting Information (HTML) Get PDF (566K)