Get access

Enzyme-Responsive Controlled Release of Covalently Bound Prodrug from Functional Mesoporous Silica Nanospheres

Authors

  • Dr. Amirali Popat,

    1. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia)
    Search for more papers by this author
  • Dr. Benjamin P. Ross,

    1. School of Pharmacy, The University of Queensland, Brisbane, QLD 4072 (Australia)
    Search for more papers by this author
  • Dr. Jian Liu,

    1. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia)
    Search for more papers by this author
  • Siddharth Jambhrunkar,

    1. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia)
    Search for more papers by this author
  • Prof. Freddy Kleitz,

    Corresponding author
    1. Department of Chemistry and Centre de recherche sur les matériaux avancés (CERMA), Université Laval, Quebec, G1V0A6, QC (Canada)
    • Department of Chemistry and Centre de recherche sur les matériaux avancés (CERMA), Université Laval, Quebec, G1V0A6, QC (Canada)
    Search for more papers by this author
  • Prof. Shi Zhang Qiao

    Corresponding author
    1. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia)
    2. School of Chemical Engineering, The University of Adelaide, SA 5005 (Australia)
    • Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia)
    Search for more papers by this author

  • This work was financially supported by the Australian Research Council (ARC) through Linkage Project program (LP0882681) and Discovery Project program (DP1095861, DP1094070, DP0987969). F.K. acknowledges financial support from the Natural Sciences and Engineering Research Council of Canada (NSERC) and the AER program of the Université Laval.

Abstract

original image

Enzymvermittelte Freisetzung: Die Funktionalisierung von mesoporösen SiO2-Nanopartikeln mit Sulfasalazin (SZ), einem Prodrug der 5-Aminosalicylsäure (5-ASA; siehe Schema) und von Sulfapyridin, ergibt enzymresponsive Nanotransporter. In Gegenwart des Kolon-spezifischen Enzyms Azo-Reduktase (orange) werden 5-ASA und Sulfapyridin effizient freigesetzt.

Get access to the full text of this article

Ancillary