Chiral Bases as Useful Probes of Lithium Amide Reactivity

Authors


  • We acknowledge the University of Birmingham for support of M.R.P. The NMR and GC instruments used in this research were obtained through Birmingham Science City: Innovative Uses for Advanced Materials in the Modern World (West Midlands Centre for Advanced Materials Project 2), with support from Advantage West Midlands (AWM) and part funded by the European Regional Development Fund (ERDF). We would also like to thank Graham Burns and Chi Tsang of the School of Chemistry for assistance with HPLC and GC.

Abstract

original image

Konkurrenzexperimente zwischen chiralen und achiralen Lithiumamiden liefern einen qualitativen Eindruck von der Kinetik verschiedener Amidstrukturen in Enolisierungen: Lithiumdiisopropylamid (LDA) setzte die Enantioselektivität asymmetrischer Enolisierungen, die von einer chiralen, aus einem 1,2-Diamin hergestellten Lithiumamid-Base vermittelt wurden, nicht herab.

Ancillary