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Intrinsically Copper-64-Labeled Organic Nanoparticles as Radiotracers

Authors

  • Tracy W. Liu,

    1. Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada)
    2. Department of Medical Biophysics, University of Toronto (Canada)
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    • These authors contributed equally to this work.

  • Thomas D. MacDonald,

    1. Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada)
    2. Department of Pharmaceutical Sciences, University of Toronto (Canada)
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    • These authors contributed equally to this work.

  • Dr. Jiyun Shi,

    1. Department of Medical Biophysics, University of Toronto (Canada)
    2. Medical Isotopes Research Center, Peking University, Beijing (China)
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  • Prof.Dr. Brian C. Wilson,

    1. Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada)
    2. Department of Medical Biophysics, University of Toronto (Canada)
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  • Prof.Dr. Gang Zheng

    Corresponding author
    1. Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada)
    2. Department of Medical Biophysics, University of Toronto (Canada)
    3. Department of Pharmaceutical Sciences, University of Toronto (Canada)
    • Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada)
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  • We would like to thank Dr. Warren Foltz for assistance with MR imaging, Tab Siddiqi and Dr. David Green for assistance with the radioUPLC, Dr. Helen Lee, Dr. Jinzi Zhang, and Dr. Wing-Ki Liu for assistance with the pharmacokinetics study, Cheng S. Jin for assistance with the orthotopic prostate cancer model, Dr. David Jaffray and the staff of the STTARR facility for assisting with obtaining 64Cu, and Todd Cunningham for illustrating Figure 2 A. Funding was provided by CIHR, OICR, SERC, CFI, the Princess Margaret Cancer Foundation, MaRS Innovation, Joey and Toby Tanenbaum/Brazilian Ball Chair in Prostate Cancer Research, and the US Army BCRP Predoctoral Award W81XWH-10-1-0115.

Abstract

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Radiochemische Markierungen für die PET-Bildgebung werden in einer Eintopfmethode mit Ausbeuten >95 % innerhalb von nur 30 min vollständig in organische Porphysomen eingebracht. Dabei resultieren Nanopartikel, die hoch stabil sind (>48 h) und über die höchste spezifische Aktivität aller bisher beschriebenen 64Cu-markierten Nanopartikel verfügen. Die 64Cu-Porphysomen können mithilfe von nichtinvasiven Verfahren exakt in vivo verfolgt werden.

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