Tracking the Bioreduction of Disulfide-Containing Cationic Dendrimers

Authors

  • Lorine Brülisauer,

    1. Swiss Federal Institute of Technology Zurich (ETHZ), Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich (Switzerland)
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  • Nadia Kathriner,

    1. Swiss Federal Institute of Technology Zurich (ETHZ), Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich (Switzerland)
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  • Mark Prenrecaj,

    1. Swiss Federal Institute of Technology Zurich (ETHZ), Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich (Switzerland)
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  • Dr. Marc A. Gauthier,

    1. Swiss Federal Institute of Technology Zurich (ETHZ), Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich (Switzerland)
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  • Prof. Dr. Jean-Christophe Leroux

    Corresponding author
    1. Swiss Federal Institute of Technology Zurich (ETHZ), Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich (Switzerland)
    • Swiss Federal Institute of Technology Zurich (ETHZ), Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Wolfgang-Pauli-Strasse 10, 8093 Zurich (Switzerland)
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  • L. B. acknowledges the Scholarship Fund of the Swiss Chemical Industry (2-70882-08). The Light Microscopy Center (ETHZ) and Alois Renn are thanked for experimental support. Ari Helenius kindly provided RFP-Rab5 plasmids.

Abstract

original image

Disulfide erhöhen die Transfektionseffizienz und vermindern die Toxizität kationischer Polymere für den Gentransport. Eine quantitative Analyse der biologischen Reduktion eines dendritischen Polykations in vier Zelllinien liefert wichtige Informationen für das Verständnis und die Optimierung biologisch reduzierbarer Wirkstoff- und Gentransportsysteme.

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