Consequences of Folding a Water-Soluble Polymer Around an Organocatalyst

Authors

  • Dr. Elisa Huerta,

    1. Laboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
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  • Patrick J. M. Stals,

    1. Laboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
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  • Prof. Dr. E. W. Meijer,

    Corresponding author
    1. Laboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
    • Laboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
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  • Dr. Anja R. A. Palmans

    Corresponding author
    1. Laboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
    • Laboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands)
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  • This work was supported by the European Research Council (ERC Advanced Grant No. 246829), the National Research School Catalysis (NRSC-C), and Marie Curie Actions SCPNANOPart FP7-PEOPLE-2010-IEF-274668 (E.H.). Z. Brdid and T. F. E. Paffen are acknowledged for their help in the synthesis. M. A. J. Gillissen and J. L. J. van Dongen are acknowledged for fruitful discussions.

Abstract

original image

Gib ihnen Struktur: Die Gegenwart strukturierender Elemente in mit katalytischen Einheiten funktionalisierten Polymeren ergab eine neue Klasse von Enzymmimetika, die nur im gefalteten Zustand aktiv sind (siehe Bild). Die konformativ anpassungsfähige hydrophobe Umgebung um das katalytische Zentrum ermöglicht die hocheffiziente Katalyse einer Aldolreaktion in Wasser mit Michaelis-Menten-Kinetik.

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