Catalytic [4+2] Cyclization of α,β-Unsaturated Acyl Chlorides with 3-Alkylenyloxindoles: Highly Diastereo- and Enantioselective Synthesis of Spirocarbocyclic Oxindoles

Authors

  • Dr. Li-Tao Shen,

    1. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (China)
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  • Wen-Qiang Jia,

    1. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (China)
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  • Prof. Dr. Song Ye

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (China)
    • Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (China)
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  • Financial support from the Ministry of Science and Technology of China (2011CB808600), National Natural Science Foundation of China (No. 21072195), and the Chinese Academy of Sciences is gratefully acknowledged.

Abstract

original image

Cinchona-Alkaloide wurden als Lewis-Base-Katalysatoren in der Titelreaktion eingesetzt. Die [4+2]-Cyclisierung von α,β-ungesättigten Acylchloriden mit elektronenarmen, von Oxindol abgeleiteten Alkenen führte zu den entsprechenden spirocarbocyclischen Oxindolen.

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