Get access

On-Demand Drug Release System for In Vivo Cancer Treatment through Self-Assembled Magnetic Nanoparticles

Authors

  • Dr. Jae-Hyun Lee,

    1. Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Dr. Kuan-Ju Chen,

    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, Los Angeles, CA 90095-1770 (USA) http://tseng-lab.com
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Seung-Hyun Noh,

    1. Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
    Search for more papers by this author
  • Dr. Mitch André Garcia,

    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, Los Angeles, CA 90095-1770 (USA) http://tseng-lab.com
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Prof. Hao Wang,

    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, Los Angeles, CA 90095-1770 (USA) http://tseng-lab.com
    2. National Center for Nanoscience and Technology, 11 Beiyitiao Zhongguancun Haidian District, Beijing, 100190 (P.R. China)
    Search for more papers by this author
  • Prof. Wei-Yu Lin,

    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, Los Angeles, CA 90095-1770 (USA) http://tseng-lab.com
    2. Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, Kaohsiung, 80708 (Taiwan)
    Search for more papers by this author
  • Heeyeong Jeong,

    1. Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
    Search for more papers by this author
  • Brian Junoh Kong,

    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, Los Angeles, CA 90095-1770 (USA) http://tseng-lab.com
    Search for more papers by this author
  • Prof. David B. Stout,

    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, Los Angeles, CA 90095-1770 (USA) http://tseng-lab.com
    Search for more papers by this author
  • Prof. Jinwoo Cheon,

    Corresponding author
    1. Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
    • Jinwoo Cheon, Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)===

      Hsian-Rong Tseng, Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, Los Angeles, CA 90095-1770 (USA) http://tseng-lab.com===

    Search for more papers by this author
  • Prof. Hsian-Rong Tseng

    Corresponding author
    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, Los Angeles, CA 90095-1770 (USA) http://tseng-lab.com
    • Jinwoo Cheon, Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)===

      Hsian-Rong Tseng, Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, Los Angeles, CA 90095-1770 (USA) http://tseng-lab.com===

    Search for more papers by this author

  • This research was supported by the NIH (grant numbers R21GM098982 and R21EB016270; H.R.T.), National Creative Research Initiative (2010-0018286; J.C.), and WCU (R32-10217; J.C.).

Abstract

original image

Wirkstoff-Freisetzung auf Abruf: Thermomagnetisch responsive supramolekulare Nanopartikel mit einem eingekapselten Wirkstoff wurden für die In-Vivo-Wirkstoff-Freisetzung auf Abruf entwickelt. Durch ein magnetisches Feld werden die Partikel aufgeheizt, was die Freisetzung des Wirkstoffs einleitet. Eine plötzlich freigesetzte Wirkstoffkonzentration kann in vivo zu einem Tumor gelangen und verbessert somit das Therapieergebnis.

Get access to the full text of this article

Ancillary