Get access
Advertisement

Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts

Authors


  • We thank the National Institutes of Health for financial support of this work (Grant GM46059). We thank Robert Todd (Aldrich) for a helpful discussion and a gift of the ZnCl2⋅THF complex. We are grateful to Dr. Laurent Pellegatti (Massachusetts Institute of Technology) for insightful discussions and Dr. Meredeth A. McGowan (Massachusetts Institute of Technology) for help with the preparation of this manuscript. We acknowledge Nicholas C. Bruno (Massachusetts Institute of Technology) for providing the precatalyst 3 used in this study. MIT has patents on some of the ligands and precatalysts used in this work from which S.L.B. receives royalty payments.

Abstract

original image

Ein breites Spektrum von Biarylen ist durch palladiumkatalysierte Negishi-Kreuzkupplungen bei Raumtemperatur oder mit geringen Katalysatormengen zugänglich, wobei die katalytisch aktive XPhosPd0-Spezies aus einem Aminobiphenyl-Palladacyclus erzeugt wird. Knifflige heterocyclische und polyfluorierte aromatische Substrate ergeben die Produkte in ausgezeichneten Ausbeuten.

Get access to the full text of this article

Ancillary