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Systemic Delivery of microRNA-34a for Cancer Stem Cell Therapy

Authors

  • Sanjun Shi,

    1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, No.17, Section 3, Renmin South Rd, Chengdu, 610041 (P.R. China)
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  • Lu Han,

    1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, No.17, Section 3, Renmin South Rd, Chengdu, 610041 (P.R. China)
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  • Prof. Tao Gong,

    1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, No.17, Section 3, Renmin South Rd, Chengdu, 610041 (P.R. China)
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  • Prof. Zhirong Zhang,

    1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, No.17, Section 3, Renmin South Rd, Chengdu, 610041 (P.R. China)
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  • Prof. Xun Sun

    Corresponding author
    1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, No.17, Section 3, Renmin South Rd, Chengdu, 610041 (P.R. China)
    • Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, No.17, Section 3, Renmin South Rd, Chengdu, 610041 (P.R. China)
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  • We thank the National Science Foundation of China (No. 81130060), the Program for New Century Excellent Talents in University (No. NTEC-10-0601), and the National Science & Technology Major Project of China (No. 2011ZX09401-304(4-3)) for financial support. We also thank Dr. Chester Provoda from the University of Michigan for his help in preparing this manuscript.

Abstract

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Abgeliefert: Ein System aus festen Lipidnanopartikeln (SLNs) wurde für den Transport von MicroRNA-34a (miR-34a; interessant für die Therapie von Krebsstammzellen (CSCs)) in Lungengewebe entwickelt. In SLNs mit miR-34a (miSLNs-34a) ist die MicroRNA vor dem Abbau im Serum geschützt, und ihre zelluläre In-vitro-Transfektionseffizienz ist erhöht. Die Behandlung mit miSLNs-34a führt daher zu einer erhöhten Überlebenswahrscheinlichkeit von mit CSCs infizierten Mäusen (siehe Bild).

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