Quantitative Analysis of the Fate of Gold Nanocages In Vitro and In Vivo after Uptake by U87-MG Tumor Cells

Authors

  • Dr. Eun Chul Cho,

    1. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130 (USA)
    2. Current address: Department of Chemical Engineering, Division of Chemical and Bioengineering, Hanyang University, Seoul, 133-791 (Korea)
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    • These authors contributed equally to this work.

  • Yu Zhang,

    1. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130 (USA)
    2. Current address: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332 (USA)
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    • These authors contributed equally to this work.

  • Xin Cai,

    1. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130 (USA)
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    • These authors contributed equally to this work.

  • Christine M. Moran,

    1. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130 (USA)
    2. Current address: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332 (USA)
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  • Prof. Lihong V. Wang,

    Corresponding author
    1. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130 (USA)
    • Department of Biomedical Engineering, Washington University, St. Louis, MO 63130 (USA)
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  • Prof. Younan Xia

    Corresponding author
    1. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130 (USA)
    2. Current address: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332 (USA)
    • Department of Biomedical Engineering, Washington University, St. Louis, MO 63130 (USA)
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  • This study was supported in part by a grant from NIH (R01 CA138527) and startup funds from Washington University in St. Louis (to Y.X.), and NIH Grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, and 5P60 DK02057933 (to L.V.W.). Part of the research was conducted at the Alafi Neuroimaging Laboratory, the Hope Center for Neurological Disorders (NIH Neuroscience Blueprint Center Core Grant P30 NS057105).

Abstract

original image

Nicht immer gleich: Wenn sich eine Gold-Nanokäfige enthaltende Mutterzelle teilt, werden die Nanopartikel nicht gleichmäßig auf die beiden Tochterzellen verteilt. Diese ungleichmäßige Verteilung der Nanopartikel sowie deren Ausscheidung aus den Zellen (siehe Bild) wurden sowohl in vitro als auch in vivo quantitativ mithilfe von Zweiphotonenmikroskopie bzw. photoakustischer Mikroskopie analysiert.

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