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Stable Aqueous Dispersions of Glycopeptide-Grafted Selectably Functionalized Magnetic Nanoparticles†

  1. Tushar Borase1,‡,
  2. Dr. Tsedev Ninjbadgar1,‡,
  3. Antonios Kapetanakis1,
  4. Dr. Sandra Roche2,
  5. Dr. Robert O'Connor2,
  6. Dr. Christian Kerskens3,
  7. Dr. Andreas Heise1,*,
  8. Dr. Dermot F. Brougham1,2,*

Article first published online: 1 FEB 2013

DOI: 10.1002/ange.201208099

Issue

Angewandte Chemie

Angewandte Chemie

Volume 125, Issue 11, pages 3246–3249, March 11, 2013

Additional Information

How to Cite

Borase, T., Ninjbadgar, T., Kapetanakis, A., Roche, S., O'Connor, R., Kerskens, C., Heise, A. and Brougham, D. F. (2013), Stable Aqueous Dispersions of Glycopeptide-Grafted Selectably Functionalized Magnetic Nanoparticles . Angew. Chem., 125: 3246–3249. doi: 10.1002/ange.201208099

Author Information

  1. 1

    School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9 (Ireland)

  2. 2

    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9 (Ireland)

  3. 3

    Institute of Neuroscience, University of Dublin, Trinity College, Dublin 2 (Ireland)

  1. ‡

    These authors contributed equally to this work.

*School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9 (Ireland)

  1. †

    T.N., C.K., and D.B. acknowledge support from Enterprise Ireland (TD20080135). S.R. acknowledges the DCU Targeted Research Initiative Fund (TRIF). A.H. and T.B. acknowledge Science Foundation Ireland for a Principle Investigator Award (07/IN1/B1792). A.K. acknowledges the IUPAC glycopeptides project (AC-POL-09-11-25). A.H. is a SFI Stokes Senior Lecturer (07/SK/B1241). We thank Dr. Cormac O’Connell, Electron Microscopy Laboratory, University College Dublin, for access to TEM facilities.

  2. ‡

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 7 MAR 2013
  2. Article first published online: 1 FEB 2013
  3. Manuscript Received: 8 OCT 2012

Funded by

  • Enterprise Ireland. Grant Number: TD20080135
  • DCU Targeted Research Initiative Fund (TRIF)
  • Science Foundation Ireland. Grant Number: 07/IN1/B1792
  • IUPAC glycopeptides project. Grant Number: AC-POL-09-11-25
  • SFI Stokes Senior Lecturer. Grant Number: 07/SK/B1241

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Keywords:

  • Glycopeptide;
  • Klick-Chemie;
  • Liganden;
  • Magnetische Nanopartikel;
  • Ringöffnungspolymerisation
Thumbnail image of graphical abstract

Suspensionen magnetischer Nanopartikel mit Glycopeptid-Beschichtung werden durch N-Carboxyanhydrid-Ringöffnungspolymerisation mit anschließender Klick-Glycosylierung erhalten. Die Materialien zeigen eine hohe Zuckereinheitendichte, optimales Dispersionsverhalten und die Fähigkeit zur Bioerkennung. Jede Kombination funktioneller Gruppen kann aufgebracht werden, wobei die Dichte nicht von der Partikeloberfläche beschränkt wird.

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