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Copper-Catalyzed Hydrodefluorination of Fluoroarenes by Copper Hydride Intermediates

Authors

  • Hongbin Lv,

    1. Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P.R. China) http://www.chem.pku.edu.cn/zhangjl/
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  • Yuan-Bo Cai,

    1. Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P.R. China) http://www.chem.pku.edu.cn/zhangjl/
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  • Prof. Dr. Jun-Long Zhang

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P.R. China) http://www.chem.pku.edu.cn/zhangjl/
    • Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P.R. China) http://www.chem.pku.edu.cn/zhangjl/

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  • This project was supported by the National Key Basic Research Support Foundation of China (NKBRSFC) (2010CB912302) and National Scientific Foundation of China (grant no. 20971007).

Abstract

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Defluorierung: Unter Kupferkatalyse können C-F-Bindungen effizient aktiviert und durch C-H-Bindungen ersetzt werden. Auf der Grundlage von experimentellen und theoretischen Studien wird ein Kupferhydrid als aktive Zwischenstufe vorgeschlagen, die den Fluorkohlenstoff nucleophil angreift (siehe Struktur; C grau, H weiß, Cu hellrot, F hellblau; Abstände in Å).

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