Fulvenes as Effective Dipolarophiles in Copper(I)-Catalyzed [6+3] Cycloaddition of Azomethine Ylides: Asymmetric Construction of Piperidine Derivatives

Authors

  • Zhao-Lin He,

    1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 (China)
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    • These authors contributed equally to this work.

  • Huai-Long Teng,

    1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 (China)
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    • These authors contributed equally to this work.

  • Prof. Dr. Chun-Jiang Wang

    Corresponding author
    1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 (China)
    2. State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, 300071 (China)
    • College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 (China)
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  • This work is supported by the 973 Program (2011CB808600), NSFC (21172176), NCET-10-0649, IRT1030, and the Fundamental Research Funds for the Central Universities.

Abstract

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Leichte Additionsübung: Fulvene agieren in der Titelreaktion in Gegenwart des chiralen CuI/(S)-L-Komplexes als 6π-Dipolarophile. Das System bietet einen einzigartigen und simplen Zugang zu enantiomerenangereicherten, hoch funktionalisierten Piperidinderivaten mit guten Ausbeuten und exzellenten Diastereo- und Enantioselektivitäten.

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