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Effective Chiral Discrimination of Tetravalent Polyamines on the Compaction of Single DNA Molecules†

  1. Prof. Dr. Yuko Yoshikawa1,*,
  2. Dr. Naoki Umezawa2,*,
  3. Yuki Imamura2,
  4. Prof. Dr. Toshio Kanbe3,
  5. Dr. Nobuki Kato2,
  6. Prof. Dr. Kenichi Yoshikawa4,
  7. Prof. Dr. Tadayuki Imanaka1,
  8. Prof. Dr. Tsunehiko Higuchi2,*

Article first published online: 25 FEB 2013

DOI: 10.1002/ange.201209144

Issue

Angewandte Chemie

Angewandte Chemie

Volume 125, Issue 13, pages 3800–3804, March 25, 2013

Additional Information

How to Cite

Yoshikawa, Y., Umezawa, N., Imamura, Y., Kanbe, T., Kato, N., Yoshikawa, K., Imanaka, T. and Higuchi, T. (2013), Effective Chiral Discrimination of Tetravalent Polyamines on the Compaction of Single DNA Molecules . Angew. Chem., 125: 3800–3804. doi: 10.1002/ange.201209144

Author Information

  1. 1

    Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577 (Japan)

  2. 2

    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)

  3. 3

    Laboratory of Medical Mycology, School of Medicine, Nagoya University, Nagoya 464-0064 (Japan)

  4. 4

    Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe 610-0394 (Japan)

*Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577 (Japan)

  1. †

    This research was supported in part by Grants-in-Aid for Scientific Research from the Japan Science and Technology Agency CREST program, and from the Japan Society for the Promotion of Science (20249006, 22510123, 23240044, 23659058, and 24590142).

Publication History

  1. Issue published online: 20 MAR 2013
  2. Article first published online: 25 FEB 2013
  3. Manuscript Revised: 26 JAN 2013
  4. Manuscript Received: 15 NOV 2012

Funded by

  • Japan Society for the Promotion of Science. Grant Numbers: 20249006, 22510123, 23240044, 23659058, 24590142

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Keywords:

  • Amine;
  • Chiralität;
  • DNA-Strukturen;
  • Einzelmolekülstudien;
  • Fluoreszenzmikroskopie
Thumbnail image of graphical abstract

Normale Donuts oder viele kleine? Von vier Stereoisomeren eines Tetraamins zeigte das abgebildete Isomer die wirksamste Induktion einer DNA-Kompaktierung, die in einzigartigen minitoroidalen Clustern resultierte. Das nichtchirale Polyamin Spermin induzierte dagegen die Bildung von typischen größeren Toroiden.

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