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Effective Chiral Discrimination of Tetravalent Polyamines on the Compaction of Single DNA Molecules

Authors

  • Prof. Dr. Yuko Yoshikawa,

    Corresponding author
    1. Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577 (Japan)
    • Yuko Yoshikawa, Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577 (Japan)===

      Naoki Umezawa, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)===

      Tsunehiko Higuchi, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)===

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  • Dr. Naoki Umezawa,

    Corresponding author
    1. Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)
    • Yuko Yoshikawa, Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577 (Japan)===

      Naoki Umezawa, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)===

      Tsunehiko Higuchi, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)===

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  • Yuki Imamura,

    1. Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)
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  • Prof. Dr. Toshio Kanbe,

    1. Laboratory of Medical Mycology, School of Medicine, Nagoya University, Nagoya 464-0064 (Japan)
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  • Dr. Nobuki Kato,

    1. Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)
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  • Prof. Dr. Kenichi Yoshikawa,

    1. Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe 610-0394 (Japan)
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  • Prof. Dr. Tadayuki Imanaka,

    1. Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577 (Japan)
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  • Prof. Dr. Tsunehiko Higuchi

    Corresponding author
    1. Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)
    • Yuko Yoshikawa, Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577 (Japan)===

      Naoki Umezawa, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)===

      Tsunehiko Higuchi, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan)===

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  • This research was supported in part by Grants-in-Aid for Scientific Research from the Japan Science and Technology Agency CREST program, and from the Japan Society for the Promotion of Science (20249006, 22510123, 23240044, 23659058, and 24590142).

Abstract

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Normale Donuts oder viele kleine? Von vier Stereoisomeren eines Tetraamins zeigte das abgebildete Isomer die wirksamste Induktion einer DNA-Kompaktierung, die in einzigartigen minitoroidalen Clustern resultierte. Das nichtchirale Polyamin Spermin induzierte dagegen die Bildung von typischen größeren Toroiden.

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