Design, Synthesis, and Biological Evaluation of Truncated Superstolide A

Authors

  • Dr. Lei Chen,

    1. Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences & Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242 (USA)
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  • Kausar Begam Riaz Ahmed,

    1. Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 (USA)
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  • Prof. Dr. Peng Huang,

    1. Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 (USA)
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  • Prof. Dr. Zhendong Jin

    Corresponding author
    1. Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences & Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242 (USA)
    • Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences & Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242 (USA)
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  • This work was made possible by the generous support of the NIH (5R01CA109208).

Abstract

original image

Worauf es ankommt: Ein vereinfachtes Analogon des marinen Makrolids Superstolid A wurde entworfen und nach einem konvergenten Ansatz hocheffizient synthetisiert. Biologische Tests belegen, dass auch diese Verbindung noch über die starke Antikrebsaktivität des Naturstoffs Superstolid A verfügt.

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