Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands: Thiol “Switch-on” Fluorescent Probes and Anti-Cancer Agents

Authors

  • Taotao Zou,

    1. Department of Chemistry, State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong (China)
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  • Dr. Ching Tung Lum,

    1. Department of Chemistry, State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong (China)
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  • Dr. Stephen Sin-Yin Chui,

    1. Department of Chemistry, State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong (China)
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  • Prof. Dr. Chi-Ming Che

    Corresponding author
    1. Department of Chemistry, State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong (China)
    • Department of Chemistry, State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong (China)
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  • This work was supported by The Innovation and Technology Commission (ITF-Tier 2 Project, ITS/134/09FP) and the University Grants Committee (Area of Excellence Scheme AoE/P-03/08) of the Hong Kong Special Administrative Region of China. We thank Dr. Raymond Wai-Yin Sun for helpful discussion and Dr. Chun-Nam Lok for help in designing the bio-experiments.

Abstract

original image

Nichtleuchtende [AuIII(N N N)(NHC)]+-Komplexe wie 1 werden in Zellen durch Glutathion zu AuI-NHC-Komplexen mit vielversprechenden Antikrebseigenschaften reduziert, wobei ein stark fluoreszierender Ligand freigesetzt wird. Das hoch effiziente Einschalten dieser Fluoreszenz macht die AuIII-Komplexe zu ausgezeichneten Sonden für den Thiolnachweis in Zellen.

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