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NIR-Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene-Modified Mesoporous Silica

Authors

  • Jianan Liu,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050 (China)
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  • Prof. Wenbo Bu,

    Corresponding author
    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050 (China)
    • State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050 (China)===

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  • Limin Pan,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050 (China)
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  • Prof. Jianlin Shi

    Corresponding author
    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050 (China)
    • State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050 (China)===

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  • This work was financially supported by the National Natural Science Foundation of China Research (grant numbers 50823007, 50972154, 51132009, 51072212, and 21172043), the Shanghai Rising-Star Program (grant number 12QH1402500), the Nano special program of the Science and Technology Commission of Shanghai (grant number 11nm0505000), the Development Foundation for Talents of Shanghai (grant number2012035), the National Basic Research Program of China (973 Program, grant number 2011CB707905).

Abstract

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Lichtvermittelte Wirkstoff-Freisetzung: Quarzbeschichtete Nanopartikel mit Azobenzol-modifizierten Mesoporen wurden synthetisiert. Die Azobenzol-Moleküle ermöglichen die Freisetzung des Tumortherapeutikums Doxorubicin (Dox) aus dem Porennetzwerk der äußeren mesoporösen Quarzschicht durch Bestrahlung mit Nahinfrarot(NIR)-Laserlicht. Die Freisetzung wird durch die trans-cis-Isomerisierung der Azobenzolmoleküle gesteuert (siehe Bild).

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