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Biodegradable ZnO@polymer Core–Shell Nanocarriers: pH-Triggered Release of Doxorubicin In Vitro

Authors

  • Dr. Zheng-Yong Zhang,

    1. Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433 (P.R. China)
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  • Yu-Dong Xu,

    1. Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200433 (P.R. China)
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  • Ying-Ying Ma,

    1. Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200433 (P.R. China)
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  • Li-Li Qiu,

    1. Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200433 (P.R. China)
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  • Dr. Yi Wang,

    1. Department of Chemistry and Center of Analysis and Measurement, Fudan University, Shanghai 200433 (P.R. China)
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  • Prof. Ji-Lie Kong,

    Corresponding author
    1. Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433 (P.R. China)
    • Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433 (P.R. China)
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  • Prof. Huan-Ming Xiong

    Corresponding author
    1. Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200433 (P.R. China)
    • Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200433 (P.R. China)
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  • This work was supported by the National Natural Science Foundation of China (20890022, 21175029, 21271045), the National Basic Research Program of China (2013CB934102), NCET-11-0115, and the Shanghai Leading Academic Discipline Project (B109).

Abstract

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Lumineszierende ZnO@Polymer-Kern/Schale-Nanopartikel wurden aufgebaut und für die Behandlung menschlicher Gehirntumor-Zellen mit Doxorubicin (DOX) beladen. Konfokale Laserscanmikroskopie zeigte, dass die ZnO@Polymer-DOX-Nanokomposite an Lysosomen zerfallen und dabei DOX-Moleküle freisetzen, die anschließend in den Zellkern eindringen und die Zellen töten (siehe Bild).

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