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Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability

Authors

  • Yanfeng Zhang,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL, 61801 (USA)
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  • Qian Yin,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL, 61801 (USA)
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  • Lichen Yin,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL, 61801 (USA)
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  • Liang Ma,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL, 61801 (USA)
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  • Li Tang,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL, 61801 (USA)
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  • Prof. Dr. Jianjun Cheng

    Corresponding author
    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL, 61801 (USA)
    • Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL, 61801 (USA)

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  • This work is supported by Dow Chemical Company. We thank Dr. Liang Hong and Dr. Keith Harris for helpful discussion. Q.Y. was funded at UIUC from NIH National Cancer Institute Alliance for Nanotechnology in Cancer “Midwest Cancer Nanotechnology Training Center” Grant R25 CA154015A.

Abstract

original image

Total zerlegt: Stimuli-responsive polymere Therapeutika, die unter völligem Kettenzerfall reagieren (CSPTs), wurden durch Kondensationspolymerisation einer UV- oder H2O2-responsiven Domäne und eines Wirkstoffs als Comonomere hergestellt. Die Wirkstoff-Freisetzung lässt sich durch An- und Absetzen des Stimulus starten bzw. stoppen. Chemotherapeutika-haltige CSPTs zeigten Stimuli-responsive In-vitro- und In-vivo-Antitumorwirksamkeit.

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