Intramolecular Larock Indole Synthesis: Preparation of 3,4-Fused Tricyclic Indoles and Total Synthesis of Fargesine

Authors

  • Dong Shan,

    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
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  • Yan Gao,

    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
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  • Prof. Yanxing Jia

    Corresponding author
    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
    2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000 (China)
    • State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
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  • We are grateful to the National Natural Science Foundation of China (Nos. 21290180, 20972007), the National Basic Research Program of China (973 Program, NO. 2010CB833200), and the Ph.D. Programs Foundation of the Ministry of Education of China (No. 20120001110100) for their financial support.

Abstract

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Zum Kern der Sache: Durch eine allgemeine Strategie gelingt der Aufbau von 3,4-verknüpften tricyclischen Indolen, den Kernstrukturen zahlreicher Naturstoffe und biologisch aktiver Verbindungen. Das entwickelte Verfahren nutzt eine einstufige intramolekulare Larock-Indolisierung; es bewährte sich in der ersten Totalsynthese von Fargesin.

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