Get access
Advertisement

Multi-Chromatic pH-Activatable 19F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical-Shift Barcodes

Authors

  • Dr. Xiaonan Huang,

    1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    Search for more papers by this author
  • Dr. Gang Huang,

    1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    Search for more papers by this author
  • Dr. Shanrong Zhang,

    1. Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    Search for more papers by this author
  • Dr. Koji Sagiyama,

    1. Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    Search for more papers by this author
  • Dr. Osamu Togao,

    1. Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    Search for more papers by this author
  • Dr. Xinpeng Ma,

    1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    Search for more papers by this author
  • Dr. Yiguang Wang,

    1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    Search for more papers by this author
  • Yang Li,

    1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    Search for more papers by this author
  • Dr. Todd C. Soesbe,

    1. Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    Search for more papers by this author
  • Dr. Baran D. Sumer,

    1. Department of Otolaryngology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    Search for more papers by this author
  • Prof. Masaya Takahashi,

    1. Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    Search for more papers by this author
  • Prof. A. Dean Sherry,

    1. Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    Search for more papers by this author
  • Prof. Jinming Gao

    Corresponding author
    1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    • Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
    Search for more papers by this author

  • This work is supported by the NIH (R01CA129011, R01EB013149). We acknowledge the assistance of the Southwestern Small Animal Imaging Resource, which is supported in part by NCI U24 CA126608, the Simmons Cancer Center through an NCI Cancer Center Support Grant (P30 CA142543).

Abstract

original image

Eine Serie von Nanosonden für die Kernspintomographie wurde aus ionisierbaren Diblockcopolymeren hergestellt und mit verschiedenen 19F-Rezeptoren für spezifische pH-Änderungen kodiert. Das pH-Signal ist extrem scharf (ΔpHAn/Aus≈0.25 pH) und resultiert aus der Dissoziation der Polymermicellen (siehe Schema). Ein System aus drei Nanosonden ermöglichte die qualitative Messung von Umgebungs-pH-Werten.

Get access to the full text of this article

Ancillary