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Organocatalytic Synthesis of Highly Functionalized Pyridines at Room Temperature

Authors

  • Dr. Zugui Shi,

    1. Division of Chemistry and Biological Chemistry, Nanyang Technological University, Singapore 637371 (Singapore)
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  • Prof. Dr. Teck-Peng Loh

    Corresponding author
    1. Hefei National Laboratory for Physical Science at the Microscale and Department of Chemistry, University of Sciences and Technology of China, Hefei, Anhui 230026 (P. R. China)
    2. Division of Chemistry and Biological Chemistry, Nanyang Technological University, Singapore 637371 (Singapore)
    • Hefei National Laboratory for Physical Science at the Microscale and Department of Chemistry, University of Sciences and Technology of China, Hefei, Anhui 230026 (P. R. China)
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  • We gratefully acknowledge the Nanyang Technological University, the Singapore Ministry of Education Academic Research Fund Tier 2 (MOE2010-T2-2-067, and MOE2011-T2-1-013) for financial support.

Abstract

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Eine einzigartige Kaskade aus Aza-Rauhut-Currier-Reaktion, Cyclisierung und Desulfonierung zwischen Allenoaten und N-Sulfonyl-1-aza-1,3-dienen gelingt mit dem leicht zugänglichen Diamin-Katalysator TMEDA. Die Reaktion bietet einen milden und effizienten Zugang zu präparativ wertvollen, hoch funktionalisierten Pyridinen.

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