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Supramolecular Iron Porphyrin/Cyclodextrin Dimer Complex that Mimics the Functions of Hemoglobin and Methemoglobin

Authors

  • Dr. Kenji Watanabe,

    1. Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan)
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  • Dr. Hiroaki Kitagishi,

    1. Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan)
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  • Prof. Dr. Koji Kano

    Corresponding author
    1. Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan)
    • Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321 (Japan)

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  • This work was supported by Grants-in-Aid on “Creating Research Center for Advanced Molecular Biochemistry”, Strategic Development of Research Infrastructure for Private Universities from the Ministry of Education, Culture, Sports, Science and Technology. We are grateful to Prof. Dr. Akira Kawaguchi for helpful discussions. The animal experiments were performed in accordance with the Guidelines for Animal Experiments of Doshisha University.

Abstract

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Lebensrettend: Das Supramolekül met-hemoCD3 (siehe Schema) resultiert aus der Verkapselung eines wasserlöslichen Porphinato-Eisen(III)-Komplexes in dem Cyclodextrin-Dimer Py3OCD, das durch eine zweistufige Synthese zugänglich ist. Die Struktur von met-hemoCD3 wurde röntgenkristallographisch bestimmt (siehe Bild). Eisen(II)-haltiges hemoCD3 hatte ähnliche Funktionen wie Hämoglobin/Myoglobin und wirkte als Gegengift für Cyanid.

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