Synthesis of Pyrroles by Click Reaction: Silver-Catalyzed Cycloaddition of Terminal Alkynes with Isocyanides

Authors

  • Meng Gao,

    1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 (P. R. China)
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    • These authors contributed equally to this work.

  • Chuan He,

    1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 (P. R. China)
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    • These authors contributed equally to this work.

  • Hongyi Chen,

    1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 (P. R. China)
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  • Ruopeng Bai,

    1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 (P. R. China)
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  • Ben Cheng,

    1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 (P. R. China)
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  • Prof. Aiwen Lei

    Corresponding author
    1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 (P. R. China)
    2. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 730000 Lanzhou (P. R. China)
    • College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 (P. R. China)

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  • This work was supported by the 973 Program (2012CB725302) and the National Natural Science Foundation of China (21025206, 21272180). We are also grateful for support from the Program for Changjiang Scholars and Innovative Research Team in University (IRT1030).

Abstract

original image

Klick, nur mit Silber: Pyrrole wurden durch Cocyclisierung endständiger Alkine und Isocyanide in einer Silber-katalysierten Klick-Reaktion hergestellt. Die Reaktion bietet einen einfachen, effizienten und atomökonomischen Zugang zu substituierten Pyrrolen in guten Ausbeuten mit hoher Selektivität und ergänzt daher die klassischen Klick-Methoden für den schnellen Aufbau multifunktioneller Heterocyclen.

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