Salicylic Acid and Analogues as diaCEST MRI Contrast Agents with Highly Shifted Exchangeable Proton Frequencies

Authors

  • Xing Yang,

    1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
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    • These authors contributed equally to this work.

  • Xiaolei Song,

    1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
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    • These authors contributed equally to this work.

  • Yuguo Li,

    1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
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  • Prof. Guanshu Liu,

    1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
    2. F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 N. Broadway Ave., Baltimore, MD 21287 (USA)
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  • Prof. Sangeeta Ray Banerjee,

    1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
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  • Prof. Martin G. Pomper,

    Corresponding author
    1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
    • The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
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  • Prof. Michael T. McMahon

    Corresponding author
    1. The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
    2. F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 N. Broadway Ave., Baltimore, MD 21287 (USA)
    • The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 991 N. Broadway Baltimore, MD 21287 (USA)
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  • Financial support from the NIH (R01EB015031, R01EB012590, R01134675, and U54CA151838) is acknowledged. diaCEST=diamagnetic chemical exchange saturation transfer, MRI=magnetic resonance imaging.

Abstract

original image

Mehr als Wasser: Bisherige Kontrastmittel für die CEST-Bildgebung nutzen Lanthanoid-gebundene Wassermoleküle für hohe Frequenzverschiebungen. Derivate der 2-Hydroxybenzoesäure mit vielversprechenden Eigenschaften als alternative CEST-MRI-Kontrastmittel werden nun beschrieben.

Ancillary