Trifluoromethylation Reactions for the Synthesis of β-Trifluoromethylamines

Authors

  • Dr. Hiromichi Egami,

    1. Synthetic Organic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
    2. Sodeoka Live Cell Chemistry Project, ERATO, Japan Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
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  • Dr. Shintaro Kawamura,

    1. Synthetic Organic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
    2. Sodeoka Live Cell Chemistry Project, ERATO, Japan Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
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  • Dr. Ayako Miyazaki,

    1. Synthetic Organic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
    2. Sodeoka Live Cell Chemistry Project, ERATO, Japan Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
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  • Prof. Dr. Mikiko Sodeoka

    Corresponding author
    1. Synthetic Organic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
    2. Sodeoka Live Cell Chemistry Project, ERATO, Japan Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
    3. RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
    • Synthetic Organic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
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  • This research was supported in part by a Grant-in-Aid for Young Scientists (B) from MEXT (No. 23750116) and by Project Funding for Basic Science from RIKEN.

Abstract

original image

Multitalent: Die N-migratorische Oxytrifluormethylierung und Eintopf-Dreikomponentenreaktionen von Allylaminen sowie die Aminotrifluormethylierung von Alkenylaminen verlaufen hocheffizient in Gegenwart des Togni-Reagens (1) und CuI. Die Umsetzungen bieten Zugang zu einer Vielfalt von β-Trifluormethylaminen (siehe Schema).

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